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复制子颗粒疫苗保护猪免受流感感染。

Replicon particle vaccine protects swine against influenza.

机构信息

Department of Animal Science, College of Agriculture, Iowa State University, Ames, IA 50010, United States.

出版信息

Comp Immunol Microbiol Infect Dis. 2010 Dec;33(6):e99-e103. doi: 10.1016/j.cimid.2010.05.002. Epub 2010 Jun 17.

DOI:10.1016/j.cimid.2010.05.002
PMID:21094422
Abstract

An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene.

摘要

一种源自甲病毒的复制子颗粒 (RP) 疫苗，表达簇 IV H3N2 猪流感病毒 (SIV) 血凝素 (HA) 基因，可诱导针对同源流感病毒攻击的保护性免疫。然而，具有母体抗体的猪在用单独表达 HA 基因或与核蛋白基因联合表达的 RP 疫苗接种后，对攻击没有保护性免疫。

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