Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 11 Kildee, Ames, IA 50011, USA.
Vaccine. 2010 Jan 8;28(3):594-6. doi: 10.1016/j.vaccine.2009.10.015. Epub 2009 Oct 22.
A propagation-defective, single-cycle, alphavirus replicon particle (RP) system was used to produce two vaccines against human influenza virus A/Wyoming/03/2003 (H3N2). One vaccine was prepared from Venezeulan equine encephalitis virus (VEEV) strain 3014 and the other from VEEV strain TC-83. Both vaccines induced high antibody titers to the influenza hemagglutinin (HA) protein and illustrated the potential of using alphavirus RP influenza vaccines in swine.
一种传播缺陷的单周期甲病毒复制子颗粒（RP）系统被用于生产两种针对人类流感病毒 A/Wyoming/03/2003（H3N2）的疫苗。一种疫苗由委内瑞拉马脑炎病毒（VEEV）株 3014 制备，另一种由 VEEV 株 TC-83 制备。两种疫苗均能诱导针对流感血凝素（HA）蛋白的高抗体滴度，并表明使用甲病毒 RP 流感疫苗在猪中的潜力。
