用于人类的黄病毒复制子颗粒疫苗可诱导猪体内高水平的流感病毒血凝素抗体：概念验证。
Alphavirus replicon particle vaccines developed for use in humans induce high levels of antibodies to influenza virus hemagglutinin in swine: proof of concept.
机构信息
Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 11 Kildee, Ames, IA 50011, USA.
出版信息
Vaccine. 2010 Jan 8;28(3):594-6. doi: 10.1016/j.vaccine.2009.10.015. Epub 2009 Oct 22.
A propagation-defective, single-cycle, alphavirus replicon particle (RP) system was used to produce two vaccines against human influenza virus A/Wyoming/03/2003 (H3N2). One vaccine was prepared from Venezeulan equine encephalitis virus (VEEV) strain 3014 and the other from VEEV strain TC-83. Both vaccines induced high antibody titers to the influenza hemagglutinin (HA) protein and illustrated the potential of using alphavirus RP influenza vaccines in swine.
一种传播缺陷的单周期甲病毒复制子颗粒（RP）系统被用于生产两种针对人类流感病毒 A/Wyoming/03/2003（H3N2）的疫苗。一种疫苗由委内瑞拉马脑炎病毒（VEEV）株 3014 制备，另一种由 VEEV 株 TC-83 制备。两种疫苗均能诱导针对流感血凝素（HA）蛋白的高抗体滴度，并表明使用甲病毒 RP 流感疫苗在猪中的潜力。
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