Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559-7435, USA.
AIDS. 2011 Jan 14;25(2):221-8. doi: 10.1097/QAD.0b013e328340fee2.
to estimate the effect of alcohol consumption on HIV acquisition while appropriately accounting for confounding by time-varying risk factors.
african-American injection drug users in the AIDS Link to Intravenous Experience cohort study. Participants were recruited and followed with semiannual visits in Baltimore, Maryland between 1988 and 2008.
marginal structural models were used to estimate the effect of alcohol consumption on HIV acquisition.
at entry, 28% of 1525 participants were women with a median (quartiles) age of 37 (32-42) years and 10 (10-12) years of formal education. During follow-up, 155 participants acquired HIV and alcohol consumption was 24, 24, 26, 17, and 9% for 0, 1-5, 6-20, 21-50, and 51-140 drinks per week over the prior 2 years, respectively. In analyses accounting for sociodemographic factors, drug use, and sexual activity, hazard ratios for participants reporting 1-5, 6-20, 21-50, and 51-140 drinks per week in the prior 2 years compared to participants who reported 0 drinks per week were 1.09 (0.60-1.98), 1.18 (0.66-2.09), 1.66 (0.94-2.93), and 2.12 (1.15-3.90), respectively. A trend test indicated a dose-response relationship between alcohol consumption and HIV acquisition (P value for trend = 9.7 × 10).
a dose-response relationship between alcohol consumption and subsequent HIV acquisition is indicated, independent of measured known risk factors.
在适当考虑随时间变化的风险因素造成的混杂影响的情况下，估计饮酒对 HIV 感染的影响。
在艾滋病关联静脉内经验队列研究中，非洲裔美国注射吸毒者。1988 年至 2008 年间，在马里兰州巴尔的摩市，以半年为间隔对参与者进行招募和随访。
使用边缘结构模型来估计饮酒对 HIV 感染的影响。
在进入研究时，1525 名参与者中有 28%为女性，中位数（四分位数）年龄为 37（32-42）岁，接受正规教育年限为 10（10-12）年。随访期间，有 155 名参与者感染了 HIV，在过去 2 年中，每周饮酒 0、1-5、6-20、21-50 和 51-140 份的参与者比例分别为 24%、24%、26%、17%和 9%。在考虑社会人口统计学因素、药物使用和性行为的分析中，与每周饮酒 0 份的参与者相比，每周报告饮酒 1-5、6-20、21-50 和 51-140 份的参与者的危险比分别为 1.09（0.60-1.98）、1.18（0.66-2.09）、1.66（0.94-2.93）和 2.12（1.15-3.90）。趋势检验表明，饮酒量与 HIV 感染之间存在剂量-反应关系（趋势检验 P 值=9.7×10）。
饮酒与随后的 HIV 感染之间存在剂量-反应关系，独立于已测量的已知风险因素。
