Rogan Walter J, Ragan N Beth
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Int J Hyg Environ Health. 2007 Oct;210(5):659-67. doi: 10.1016/j.ijheh.2007.07.005. Epub 2007 Sep 17.
Pollutant chemicals that are widespread in the environment can affect endocrine function in laboratory experiments and in wildlife. Although human beings are commonly exposed to such pollutant chemicals, the exposures are generally low and clear effects on endocrine function from such exposures have been difficult to demonstrate. Human data including both exposure to the chemical agent and the endocrine outcome are reviewed here, including age at weaning, age at puberty, anogenital distance, and sex ratio at birth, and the strength of the evidence are discussed. Although endocrine disruption in humans by pollutant chemicals remains largely undemonstrated, the underlying science is sound and the potential for such effects is real.
环境中广泛存在的污染性化学物质会在实验室实验和野生动物中影响内分泌功能。尽管人类通常会接触此类污染性化学物质，但接触程度一般较低，且难以证明此类接触会对内分泌功能产生明显影响。本文综述了包括化学物质接触情况和内分泌结果的人类数据，其中涉及断奶年龄、青春期年龄、肛殖距和出生时的性别比，并讨论了证据的力度。尽管污染性化学物质对人类内分泌的干扰在很大程度上仍未得到证实，但相关基础科学是合理的，此类影响的可能性也是真实存在的。
