University of Texas at Dallas, USA.
J Speech Lang Hear Res. 2011 Aug;54(4):1077-88. doi: 10.1044/1092-4388(2010/10-0093). Epub 2010 Nov 24.
To describe quality indicators for appraising studies of diagnostic accuracy and to report a meta-analysis of measures for diagnosing language impairment (LI) in bilingual Spanish-English U.S. children.
The authors searched electronically and by hand to locate peer-reviewed English-language publications meeting inclusion criteria; the authors rated quality features, calculated accuracy metrics and confidence intervals, and generated forest plots.
Of 771 citations (86 unique) located initially, accuracy metrics could be calculated for 17 index measures studied in a total of 100 children with LI and 109 with typical language. Most studies lacked clear descriptions of reference standards, procedures, and controls for subjective bias, making it difficult to rate specific quality features with confidence. Positive likelihood ratios (LR+) for most measures were at least diagnostically suggestive (pooled LR+ = 4.12; 95% CI [2.94, 5.78]). Negative likelihood ratios (LR-) were also generally suggestive, but heterogeneity precluded averaging. For every measure, confidence intervals for LR+ and LR- included diagnostically uninformative values.
The available evidence does not support strong claims concerning the diagnostic accuracy of these measures, but a number appear promising. Several steps are suggested for strengthening future investigations of diagnostic accuracy.
描述用于评估诊断准确性研究的质量指标,并报告一项针对双语(西班牙语-英语)美国儿童语言障碍(LI)诊断的衡量标准的荟萃分析。
作者通过电子和手工搜索,定位符合纳入标准的同行评审英文出版物;作者对质量特征进行评估,计算准确性指标和置信区间,并生成森林图。
最初共定位到 771 条引文(86 个唯一),可计算 17 项指标的准确性,这些指标共研究了 100 名 LI 儿童和 109 名典型语言儿童。大多数研究缺乏对参考标准、程序和主观偏倚控制的明确描述,使得难以有信心地对特定质量特征进行评分。大多数措施的阳性似然比(LR+)至少具有诊断提示性(合并 LR+ = 4.12;95%置信区间 [2.94, 5.78])。LR- 也通常具有提示性,但异质性妨碍了平均值的计算。对于每种措施,LR+和 LR-的置信区间都包含无诊断价值的数值。
现有证据不支持这些措施具有很强诊断准确性的说法,但其中一些措施似乎很有前景。建议采取几个步骤来加强未来对诊断准确性的研究。