Department of Chemistry, Shands Cancer Center, University of Florida Genetics Institute, Gainesville, FL 32611-7200, USA.
Nanoscale. 2011 Feb;3(2):546-56. doi: 10.1039/c0nr00646g. Epub 2010 Nov 25.
In recent years, nanomaterials have captured the attention of scientists from a wide spectrum of domains. With their unique properties, nanomaterials offer great promise for numerous applications, ranging from catalysis to energy harvesting and information technology. Functionalized with the desired biomolecules, nanomaterials can also be utilized for many biomedical applications. This paper summarizes recent achievements in the use of aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications. First, we discuss the features and properties of aptamers and then illustrate the use of aptamer-conjugated nanomaterials as sensing platforms and delivery vehicles, emphasizing how such integration can result in enhanced sensitivity and selectivity.
近年来,纳米材料引起了来自广泛领域的科学家的关注。由于其独特的性质,纳米材料在许多应用中具有广阔的前景,从催化到能源收集和信息技术。通过与所需的生物分子功能化,纳米材料也可用于许多生物医学应用。本文总结了近年来使用适体偶联纳米材料进行生物分析和生物技术应用的最新成果。首先,我们讨论了适体的特点和性质,然后说明了适体偶联纳米材料作为传感平台和输送载体的应用,强调了这种集成如何提高灵敏度和选择性。