适配体偶联纳米材料及其应用。
Aptamer-conjugated nanomaterials and their applications.
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, PR China.
出版信息
Adv Drug Deliv Rev. 2011 Nov;63(14-15):1361-70. doi: 10.1016/j.addr.2011.10.002. Epub 2011 Oct 14.
Abstract
The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.
摘要
适配体与新型纳米材料的结合，包括基于纳米材料的适配体生物缀合物，引起了相当大的关注，并导致了各种各样的应用。在这篇综述中，我们讨论了各种纳米材料，包括金、硅和磁性纳米粒子，以及碳纳米管、水凝胶、脂质体和胶束，如何被用于对适配体进行功能化，以实现各种应用。这些适配体功能化材料在放大生物传感、癌细胞特异性识别、高效分离和靶向药物输送方面取得了进展。
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