Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, São Paulo, SP, Brazil.
J Assist Reprod Genet. 2011 May;28(5):399-404. doi: 10.1007/s10815-010-9516-2. Epub 2010 Nov 26.
To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response.
Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (n = 34), patients who produced ≤4 oocytes; and Normoresponder group (n = 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles' outcomes and aneuploidy frequency.
There were no significant differences between and groups regarding the fertilization rate (p = 0.6861), clinical pregnancy (p = 0.9208), implantation (p = 0.6863), miscarriage (p = 0.6788) and the percentage of aneuploid embryos (p = 0.270). Embryo transfer rate was significantly lower on poor responder group (p = 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (p = 0.016).
Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.
检验以下假设，即与卵巢反应正常的高龄女性相比，卵巢反应不良的高龄女性胚胎染色体改变的发生率更高。
将接受卵胞浆内单精子注射并进行胚胎植入前遗传学筛查的夫妇分为两组：卵巢反应不良组（n=34），即获得≤4 个卵母细胞的患者；卵巢反应正常组（n=50），即获得≥5 个卵母细胞的患者。比较两组的周期结局和非整倍体频率。
两组间受精率（p=0.6861）、临床妊娠率（p=0.9208）、种植率（p=0.6863）、流产率（p=0.6788）和非整倍体胚胎比例（p=0.270）均无统计学差异。卵巢反应不良组的胚胎移植率显著降低（p=0.0128），逻辑回归证实卵巢反应不良对胚胎移植机会的影响（p=0.016）。
卵巢反应不良的高龄女性在体外产生非整倍体胚胎的风险并不更高。
