五味子乙素可预防大鼠皮肤组织因太阳照射导致的氧化应激。
Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue.
机构信息
Division of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China.
出版信息
Fitoterapia. 2011 Apr;82(3):393-400. doi: 10.1016/j.fitote.2010.11.018. Epub 2010 Nov 23.
Schisandrin B (Sch B) and schisandrin C (Sch C), but not schisandrin A and dimethyl diphenyl bicarboxylate, protected rat skin tissue against solar irradiation-induced oxidative injury, as evidenced by a reversal of solar irradiation-induced changes in cellular reduced glutathione and α-tocopherol levels, as well as antioxidant enzyme activities and malondialdehyde production. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production in rat skin microsomes. Taken together, Sch B or Sch C, by virtue of its pro-oxidant action and the subsequent eliciting of a glutathione antioxidant response, may prevent photo-aging of skin.
五味子丙素（Sch B）和五味子丙素 C（Sch C），而不是五味子甲素和二甲基二苯甲酰基丁二酸，可防止大鼠皮肤组织受到太阳辐射引起的氧化损伤，这可通过逆转太阳辐射引起的细胞还原型谷胱甘肽和α-生育酚水平以及抗氧化酶活性和丙二醛产生的变化来证明。细胞色素 P-450 介导的 Sch B 或 Sch C 的代谢导致大鼠皮肤微粒体中 ROS 的产生。总之，Sch B 或 Sch C 可能通过其促氧化剂作用和随后引发谷胱甘肽抗氧化反应来预防皮肤光老化。
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