Département de pathologie et biologie cellulaire, Groupe de Recherche sur le Système Nerveux Central, Centred' Excellence en Neuromique de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada.
Prog Brain Res. 2010;187:47-61. doi: 10.1016/B978-0-444-53613-6.00004-6.
The nervous system can generate rhythms of various frequencies; on the low-frequency side, we have the circuits regulating circadian rhythms with a 24-h period, while on the high-frequency side we have the motor circuits that underlie flight in a hummingbird. Given the ubiquitous nature of rhythms, it is surprising that we know very little of the cellular and molecular mechanisms that produce them in the embryos and of their potential role during the development of neuronal circuits. Recently, zebrafish has been developed as a vertebrate model to study the genetics of neural development. Zebrafish offer several advantages to the study of nervous system development including optical and electrophysiological analysis of neuronal activity even at the earliest embryonic stages. This unique combination of physiology and genetics in the same animal model has led to insights into the development of neuronal networks. This chapter reviews work on the development of zebrafish motor rhythms and speculates on birth and maturation of the circuits that produce them.
神经系统可以产生各种频率的节律；在低频侧，我们有调节昼夜节律的电路，其周期为 24 小时，而在高频侧，我们有 hummingbird 飞行的运动电路。鉴于节律的普遍存在性，令人惊讶的是，我们对胚胎中产生它们的细胞和分子机制以及它们在神经元回路发育过程中的潜在作用知之甚少。最近，斑马鱼已被开发为研究神经发育的脊椎动物模型。斑马鱼在研究神经系统发育方面具有几个优势，包括在最早的胚胎阶段对神经元活动进行光学和电生理学分析。这种在同一动物模型中生理和遗传的独特结合，使人们对神经网络的发育有了深入的了解。本章回顾了斑马鱼运动节律发育方面的工作，并推测了产生这些节律的电路的诞生和成熟。
