Jankowsky Anja, Guenther Ulf-Peter, Jankowsky Eckhard
Department of Biochemistry, Center for RNA Molecular Biology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA.
Nucleic Acids Res. 2011 Jan;39(Database issue):D338-41. doi: 10.1093/nar/gkq1002. Epub 2010 Nov 25.
RNA helicases are ubiquitous and essential enzymes that function in nearly all aspects of RNA metabolism. The RNA helicase database (www.rnahelicase.org) integrates the wealth of accumulating information on RNA helicases in a readily accessible format. The database is a portal that allows straightforward retrieval of comprehensive information on sequence, structure and on biochemical and cellular functions of all RNA helicases from the most widely used model organisms Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Also included are RNA helicases from other organisms that are subject to specific investigation. The database is structured according to the most recent helicase classification into helicase superfamilies (SFs) and families, and thus emphasizes phyologenetic relations between RNA helicases as well. Information on individual RNA helicases can be accessed through various browsing routes or through text-based searches of the database.
RNA解旋酶是普遍存在且必不可少的酶，几乎在RNA代谢的所有方面都发挥作用。RNA解旋酶数据库（www.rnahelicase.org）以易于访问的格式整合了关于RNA解旋酶的大量积累信息。该数据库是一个门户网站，可直接检索来自最广泛使用的模式生物大肠杆菌、酿酒酵母、秀丽隐杆线虫、黑腹果蝇、小鼠和人类的所有RNA解旋酶的序列、结构以及生化和细胞功能的全面信息。还包括来自其他正在进行特定研究的生物的RNA解旋酶。该数据库根据最新的解旋酶分类，分为解旋酶超家族（SFs）和家族，因此也强调了RNA解旋酶之间的系统发育关系。有关单个RNA解旋酶的信息可以通过各种浏览路径或通过基于文本的数据库搜索来获取。
