Yellaboina Sailu, Tasneem Asba, Zaykin Dmitri V, Raghavachari Balaji, Jothi Raja
Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Nucleic Acids Res. 2011 Jan;39(Database issue):D730-5. doi: 10.1093/nar/gkq1229. Epub 2010 Nov 27.
DOMINE is a comprehensive collection of known and predicted domain-domain interactions (DDIs) compiled from 15 different sources. The updated DOMINE includes 2285 new domain-domain interactions (DDIs) inferred from experimentally characterized high-resolution three-dimensional structures, and about 3500 novel predictions by five computational approaches published over the last 3 years. These additions bring the total number of unique DDIs in the updated version to 26,219 among 5140 unique Pfam domains, a 23% increase compared to 20,513 unique DDIs among 4346 unique domains in the previous version. The updated version now contains 6634 known DDIs, and features a new classification scheme to assign confidence levels to predicted DDIs. DOMINE will serve as a valuable resource to those studying protein and domain interactions. Most importantly, DOMINE will not only serve as an excellent reference to bench scientists testing for new interactions but also to bioinformaticans seeking to predict novel protein-protein interactions based on the DDIs. The contents of the DOMINE are available at http://domine.utdallas.edu.
DOMINE是一个全面的已知和预测的结构域-结构域相互作用（DDI）集合，它由15个不同来源汇编而成。更新后的DOMINE包括从经过实验表征的高分辨率三维结构推断出的2285个新的结构域-结构域相互作用（DDI），以及过去3年发表的五种计算方法做出的约3500个新预测。这些新增内容使更新版本中5140个独特的 Pfam 结构域中的独特DDI总数达到26219个，与上一版本中4346个独特结构域中的20513个独特DDI相比增加了23%。更新版本现在包含6634个已知的DDI，并采用了一种新的分类方案来为预测的DDI分配置信水平。DOMINE将成为研究蛋白质和结构域相互作用的人员的宝贵资源。最重要的是，DOMINE不仅将作为 bench 科学家测试新相互作用的优秀参考，也将作为寻求基于DDI预测新型蛋白质-蛋白质相互作用的生物信息学家的优秀参考。DOMINE的内容可在http://domine.utdallas.edu获取。
