Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC.
Phytomedicine. 2011 Jan 15;18(2-3):148-50. doi: 10.1016/j.phymed.2010.06.017. Epub 2010 Nov 5.
Reactive oxygen species and granule proteases produced by neutrophils contribute to the pathogenesis of inflammatory diseases. The extracts of the roots and the leaves of Salvia nipponica var. formosana were showed potent inhibitory effects on superoxide anion production in fMLP/CB-activated human neutrophils as well as other anti-inflammatory effects, and led to the isolation of 25 compounds. Among them, compounds 8, 12, 13, 14, 15, 17 and 20 were exhibited more potent inhibitory effect on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB. Moreover, those isolated compounds also showed significant anticholinesterase and antioxidative activities. To the best of our knowledge, this is the first report of phytochemical and biological activity study on S. nipponica var. formosana.
活性氧物质和中性粒细胞产生的颗粒蛋白酶有助于炎症性疾病的发病机制。经过研究表明，丹参变种台湾三叶升麻的根和叶提取物对 fMLP/CB 激活的人中性粒细胞中超氧阴离子的产生具有很强的抑制作用，同时还具有其他抗炎作用，并从中分离得到 25 种化合物。其中，化合物 8、12、13、14、15、17 和 20 对 fMLP/CB 刺激人中性粒细胞中超氧阴离子生成和弹性蛋白酶释放的抑制作用更强。此外，这些分离得到的化合物还具有显著的抗胆碱酯酶和抗氧化活性。据我们所知，这是对丹参变种台湾三叶升麻进行植物化学和生物活性研究的首次报道。
