Menzies Research Institute, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia.
Mamm Genome. 2011 Feb;22(1-2):32-42. doi: 10.1007/s00335-010-9302-6. Epub 2010 Nov 30.
Malaria is a disease that infects over 500 million people, causing at least 1 million deaths every year, with the majority occurring in developing countries. The current antimalarial arsenal is becoming dulled due to the rapid rate of resistance of the parasite. However, in populations living in malaria-endemic regions there are many examples of genetic-based resistance to the severe effects of the parasite Plasmodium. Defining the genetic factors behind host resistance has been an area of great scientific interest over the last few decades; this review summarizes the current knowledge of the genetic loci involved. Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials.
疟疾是一种感染超过 5 亿人的疾病，每年导致至少 100 万人死亡，其中大多数发生在发展中国家。由于寄生虫的抗药性迅速增强，目前的抗疟药物储备正在减弱。然而，在疟疾流行地区生活的人群中，有许多例子表明，遗传因素可以抵抗寄生虫疟原虫的严重影响。在过去几十年中，确定宿主抗药性背后的遗传因素一直是一个非常有科学意义的领域；这篇综述总结了目前涉及的遗传基因座的知识。也许从人类种群和实验性感染的小鼠模型的自然变异中吸取的教训可能为新型抗疟药物铺平道路。
