非整倍体作为金属致癌作用中的早期机制事件。
Aneuploidy as an early mechanistic event in metal carcinogenesis.
机构信息
Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, 96 Falmouth Street, Portland, ME 04104, USA.
出版信息
Biochem Soc Trans. 2010 Dec;38(6):1650-4. doi: 10.1042/BST0381650.
Abstract
Aneuploidy has recently been proposed as an initiating event for carcinogenesis. There is significant evidence that carcinogenic metals induce aneuploidy. Here we review the mechanisms for how carcinogenic metals may induce aneuploidy and the evidence that carcinogenic metals induce an aneugenic effect which can destabilize the genome leading to genomic instability and cancer.
摘要
非整倍性最近被提出作为致癌作用的起始事件。有大量证据表明致癌金属诱导非整倍性。在这里，我们综述了致癌金属诱导非整倍性的机制以及致癌金属诱导变倍作用的证据，这种变倍作用可以使基因组不稳定，导致基因组不稳定性和癌症。
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