有多少气雾剂能到达喘息婴幼儿的肺部？
How much aerosol reaches the lungs of wheezy infants and toddlers?
作者信息
Salmon B, Wilson N M, Silverman M
机构信息
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
出版信息
Arch Dis Child. 1990 Apr;65(4):401-3. doi: 10.1136/adc.65.4.401.
Using sodium cromoglycate as a non-toxic marker, we assessed the delivery of aerosol to nine wheezy infants and seven healthy adults. The drug was delivered to the infants by face mask and spacer device from a metered dose inhaler, and by face mask and nebuliser to the infants and the adults who breathed though their noses. The concentration of sodium cromoglycate was estimated in timed urine collections to find out how much of the dose was absorbed from the lung. Only 0.13% to 0.61% of the 20 mg nominal dose was detected in the urine, representing an estimated 0.3% to 1.5% deposited in the lung. Nasal filtration of aerosol could be a critical factor in reducing lung deposition.
我们使用色甘酸钠作为无毒标记物，评估了气雾剂在9名喘息婴儿和7名健康成年人中的递送情况。通过定量吸入器经面罩和储雾罐将药物递送给婴儿，对于经鼻呼吸的婴儿和成年人，则通过面罩和雾化器给药。通过定时收集尿液来估算色甘酸钠的浓度，以确定有多少剂量的药物从肺部吸收。在尿液中仅检测到20毫克标称剂量的0.13%至0.61%，这表明估计有0.3%至1.5%的药物沉积在肺部。气雾剂的鼻腔过滤可能是减少肺部沉积的关键因素。
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