基于契伦科夫辐射的分子影像学潜力。
On the potential for molecular imaging with Cerenkov luminescence.
机构信息
Advanced Radiological Sciences, Department of Radiology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9058, USA.
出版信息
Opt Lett. 2010 Dec 1;35(23):3889-91. doi: 10.1364/OL.35.003889.
Abstract
Recent observation of optical luminescence due to beta decay from suitable radiotracers has led to the possible development of new preclinical optical imaging methods. The generation of photons that can be detected using instrumentation optimized for bioluminescence imaging has been putatively associated with the Cerenkov effect. We describe the simultaneous utilization of fluorescence reporters to convert Cerenkov luminescence to longer wavelengths for better tissue penetration and also for modulating the luminescence spectrum for potential molecular imaging strategies.
摘要
最近，通过适当的放射性示踪剂观察到β衰变引起的光学发光，这可能导致新的临床前光学成像方法的发展。可以使用针对生物发光成像进行优化的仪器检测到的光子的产生据称与切伦科夫效应有关。我们描述了同时利用荧光报告物将切伦科夫光转换为更长的波长，以实现更好的组织穿透，并且还调制发光光谱，以用于潜在的分子成像策略。
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