Yu Lixiang, Liu Liyuan, Wang Fei, Zhou Fei, Xiang Yujuan, Huang Shuya, Yin Gengshen, Zhuo Yingjie, Ma Zhongbing, Zhang Qiang, Yu Zhigang
Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, Shandong 250033, P.R. China.
Oncol Lett. 2019 Mar;17(3):2737-2744. doi: 10.3892/ol.2019.9898. Epub 2019 Jan 7.
The association between dairy intake and breast cancer risk has not been well investigated, especially in the Chinese population. This study aimed to examine the association between the weekly frequency of dairy intake and the risk of breast cancer among women in Northern and Eastern China, and to investigate whether the association varied by hormone receptor status. A total of 1,286 cases of breast cancer and 1,461 controls were enrolled in this study. Dairy intake was obtained using a food-frequency questionnaire (FFQ). Frequency of dairy intake per week was divided into four categories (<1 day/week, 1-2 days/week, 3-4 days/week and 5-7 days/week). Unconditional multivariate logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). Stratified analyses were performed by residence, age, and education level. Separate analyses were also conducted for different estrogen receptor (ER) and progesterone receptor (PR) status. This analysis revealed that weekly frequency of dairy intake was strongly inversely associated with breast cancer risk, with an adjusted OR for intake 5-7 days/week of 0.53 (95% CI=0.39-0.72, P<0.001 for trend). In the stratified analyses, women who consumed dairy 5-7 days/week had a lower risk of breast cancer in urban areas (OR=0.45, 95% CI=0.30-0.66, P<0.001 for trend), in the group 45-59 years old (OR=0.39, 95% CI=0.26-0.60, P<0.001 for trend), and in the group educated to senior high school or above (OR=0.39, 95% CI=0.25-0.59, P<0.001 for trend). There was an inverse association between the weekly frequency of dairy intake and the risk of ER, PR, and ERPR breast cancer (all P<0.001 for trend). These results indicated that the weekly frequency of dairy intake was inversely associated with the risk of breast cancer among women in Northern and Eastern China.
乳制品摄入量与乳腺癌风险之间的关联尚未得到充分研究，尤其是在中国人群中。本研究旨在探讨中国北方和东部女性每周乳制品摄入频率与乳腺癌风险之间的关联，并调查这种关联是否因激素受体状态而异。本研究共纳入1286例乳腺癌病例和1461例对照。通过食物频率问卷（FFQ）获取乳制品摄入量。每周乳制品摄入频率分为四类（<1天/周、1 - 2天/周、3 - 4天/周和5 - 7天/周）。采用无条件多因素逻辑回归分析来估计比值比（OR）和95%置信区间（95%CI）。按居住地、年龄和教育水平进行分层分析。还针对不同的雌激素受体（ER）和孕激素受体（PR）状态进行了单独分析。该分析显示，每周乳制品摄入频率与乳腺癌风险呈强烈负相关，每周摄入5 - 7天的调整后OR为0.53（95%CI = 0.39 - 0.72，趋势P<0.001）。在分层分析中，每周摄入乳制品5 - 7天的女性在城市地区患乳腺癌的风险较低（OR = 0.45，95%CI = 0.30 - 0.66，趋势P<0.001），在45 - 59岁组（OR = 0.39，95%CI = 0.26 - 0.60，趋势P<0.001），以及在高中及以上学历组（OR = 0.39，95%CI = 0.25 - 0.59，趋势P<0.001）。每周乳制品摄入频率与ER、PR和ERPR乳腺癌风险之间存在负相关（所有趋势P<0.001）。这些结果表明，中国北方和东部女性每周乳制品摄入频率与乳腺癌风险呈负相关。
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