检测宫颈病变女性口腔黏膜中人乳头瘤病毒（HPV）及其与口交行为的关系。
Detection of Human Papilloma Virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices.
机构信息
Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, México.
出版信息
Infect Agent Cancer. 2010 Dec 4;5(1):25. doi: 10.1186/1750-9378-5-25.
BACKGROUND
Previous studies have either investigated the relationship of HPV with oral cancer or the prevalence of HPV on the oral cavity. The purpose of this investigation was to study the prevalence of HPV in oral cavity of women with oral sex practices and cervical lesions.
METHODS
Forty six (46) non-smokers and non-alcoholic patients attended the "Clínica de Displasias" of "Ciudad Juarez" were sampled. This population had a CIN diagnosis sometime between the previous six months. On previous consent they filled out a questionnaire related to their oral sex practices. Afterwards one swab from cheeks and another from palate/gum were taken; PCR was used to determine generic HPV, HPV16 and HPV18.
RESULTS
Seventy two percent (72%) of the patients stated to have oral sex practices regularly which all of them were positive to HPV either in oral mucus, palate/gum or both. The total of the given results showed that 35% had HPV16; among those distributed in 26% with regular oral sex practices and 9% stated as never practiced oral sex. An association was found between oral HPV16 positivity and progression to cervical CIN advanced lesions. On the other hand HPV18 was not detected. The frequency of HPV16 was higher in buccal mucosa (23%) versus palate/gum (16%).
CONCLUSIONS
This study suggests that buccal HPV16 infection is associated with CIN progression.
背景
之前的研究要么调查了 HPV 与口腔癌的关系，要么调查了 HPV 在口腔中的流行情况。本研究旨在研究有口交行为和宫颈病变的女性口腔中 HPV 的流行情况。
方法
46 名（46）不吸烟和不酗酒的患者在“华雷斯城的 Displasias 诊所”接受了采样。这群人在过去六个月内被诊断出患有 CIN。在之前的同意下，他们填写了一份与口交行为有关的问卷。然后从脸颊和上颚/牙龈各取一个拭子；使用 PCR 来确定通用 HPV、HPV16 和 HPV18。
结果
72%（72%）的患者表示有规律的口交行为，他们的口腔粘液、上颚/牙龈或两者都呈 HPV 阳性。总的来说，有 35%的人 HPV16 呈阳性；其中 26%的人有规律的口交行为，9%的人表示从未有过口交行为。口腔 HPV16 阳性与宫颈 CIN 进展性病变之间存在关联。另一方面，未检测到 HPV18。颊黏膜 HPV16 感染的频率（23%）高于上颚/牙龈（16%）。
结论
本研究表明，颊黏膜 HPV16 感染与 CIN 进展有关。
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