多功能 FePt 纳米颗粒用于癌症的辐射引导靶向和成像。
Multifunctional FePt nanoparticles for radiation-guided targeting and imaging of cancer.
机构信息
Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.
出版信息
Ann Biomed Eng. 2011 Mar;39(3):946-52. doi: 10.1007/s10439-010-0219-8. Epub 2010 Dec 4.
Abstract
A multifunctional FePt nanoparticle was developed that targets tumor microvasculature via "radiation-guided" peptides, and is detected by both near-infrared (NIR) fluorescence imaging and analytical mass spectrometry methods. Tumor specific binding was first measured by biotinylated peptide linked to fluorophore-conjugated streptavidin. This showed tumor selective binding to tumors using the HVGGSSV peptide. FePt nanoparticles were synthesized sequentially by surface modification with poly(L)lysine, poly(ethylene) glycol conjugation, and functionalized with HVGGSSV peptide and fluorescent probe Alexa fluor 750. NIR fluorescence imaging and ICP-MS analysis showed significant HVGGSSV-FePt nanoparticle binding to irradiated tumors as compared to unirradiated tumors and controls. Results indicate that multifunctional FePt nanoparticles have potential application for radiation-guided targeting and imaging of cancer.
摘要
一种多功能 FePt 纳米颗粒被开发出来，它通过“辐射引导”肽靶向肿瘤微血管，并通过近红外（NIR）荧光成像和分析质谱方法进行检测。首先通过与荧光团缀合的链霉亲和素连接的生物素化肽来测量肿瘤特异性结合。这表明 HVGGSSV 肽对肿瘤具有肿瘤选择性结合。通过聚（L）赖氨酸表面修饰、聚乙二醇缀合以及 HVGGSSV 肽和荧光探针 Alexa fluor 750 的功能化，依次合成了 FePt 纳米颗粒。与未辐照肿瘤和对照相比，NIR 荧光成像和 ICP-MS 分析显示出 HVGGSSV-FePt 纳米颗粒与辐照肿瘤的显著结合。结果表明，多功能 FePt 纳米颗粒具有用于癌症的辐射引导靶向和成像的潜力。
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