Pignolo Robert J, Shore Eileen M
Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104-6081, USA.
Crit Rev Eukaryot Gene Expr. 2010;20(2):171-80. doi: 10.1615/critreveukargeneexpr.v20.i2.70.
Circulating osteogenic precursor (COP) cells are blood-borne cells that express a variety of osteoblastic markers and are able to form bone in vivo. Strong evidence suggests that COP cells are derived from bone marrow and are of hematopoietic origin. The study of COP cells has been limited by several factors, including the difficulty in establishing long-term cultures and lack of a standardized protocol for their isolation and identification. However, experimental evidence supports that COP cells seed sites of injury and inflammation in response to homing signals and are involved in processes of pubertal growth, fracture, and diverse conditions of heterotopic bone formation. The role of COP cells in physiologic and pathophysiologic conditions of de novo bone formation suggests that they may serve as future targets for diagnostic measurements and therapeutic interventions.
循环成骨前体细胞（COP细胞）是一类血源性细胞，表达多种成骨细胞标志物，并且能够在体内形成骨组织。有力证据表明，COP细胞来源于骨髓，具有造血起源。对COP细胞的研究受到多种因素限制，包括建立长期培养的困难以及缺乏分离和鉴定它们的标准化方案。然而，实验证据支持COP细胞会响应归巢信号而在损伤和炎症部位定植，并参与青春期生长、骨折以及多种异位骨形成情况的过程。COP细胞在生理性和病理性骨形成中的作用表明，它们可能成为未来诊断检测和治疗干预的靶点。
