Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India.
Int J Biol Macromol. 2011 Mar 1;48(2):234-8. doi: 10.1016/j.ijbiomac.2010.11.013. Epub 2010 Dec 4.
Gene delivery can particularly be used for the treatment of diseases by the insertion of genetic materials (DNA and RNA) into mammalian cells either to express new proteins or to prevent the expression of existing proteins. Chitosan, a natural polymer is nontoxic, biocompatible, and biodegradable and it is used as a support material for gene delivery. However, practical use of chitosan has been mainly limited to its unmodified forms, and thus modified chitosans can be used for the wide range of biomedical applications including the interaction and intracellular delivery of genetic materials. In this context, this review paper provides the recent development on chitosan derivatives available for gene delivery.
基因传递特别可用于通过将遗传物质（DNA 和 RNA）插入哺乳动物细胞中，来治疗疾病，以表达新的蛋白质或防止现有蛋白质的表达。壳聚糖是一种天然聚合物，具有无毒、生物相容和可生物降解的特点，可用作基因传递的支持材料。然而，壳聚糖的实际应用主要限于其未修饰形式，因此修饰的壳聚糖可用于广泛的生物医学应用，包括遗传物质的相互作用和细胞内传递。在这种情况下，本文综述了用于基因传递的壳聚糖衍生物的最新进展。
