Movement Disorders Center, Dept. of Neurology, Inselspital, Berne University Hospital and University of Berne, Switzerland.
Brain Cogn. 2011 Mar;75(2):135-40. doi: 10.1016/j.bandc.2010.10.015. Epub 2010 Dec 4.
It is still unclear, whether patients with Parkinson's disease (PD) are impaired in the incidental learning of different motor sequences in short succession, although such a deficit might greatly impact their daily life. The aim of this study was thus to clarify the relation between disease parameters of PD and incidental motor learning of two different sequences in short succession. Results revealed that the PD patients were able to acquire two sequences in short succession but needed more time than healthy subjects. However, both the severity of axial manifestations, as assessed on a subsection of the Unified Parkinson's Disease Rating Scale III (UPDRS III) and the Hoehn and Yahr score, and the levodopa-equivalent dose (LED) were negatively correlated with the sequence learning performance. These findings indicate that, although PD patients are able to learn two sequences in short succession, they need more time and their overall sequence learning performance is strongly correlated with the stage of disease.
虽然帕金森病（PD）患者在短时间内连续学习不同的运动序列时可能存在障碍，这极大地影响了他们的日常生活，但目前尚不清楚这一情况。因此，本研究旨在阐明 PD 患者的疾病参数与短时间内连续学习两种不同运动序列之间的关系。结果表明，PD 患者能够在短时间内学习两个序列，但需要的时间比健康受试者多。然而，统一帕金森病评定量表第三部分（UPDRS III）和 Hoehn 和 Yahr 评分评估的轴性表现的严重程度以及左旋多巴等效剂量（LED）均与序列学习表现呈负相关。这些发现表明，尽管 PD 患者能够在短时间内学习两个序列，但他们需要更多的时间，并且他们的整体序列学习表现与疾病的阶段密切相关。
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