Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Box 4064, 141 04, Huddinge, Sweden.
Clin Oral Investig. 2012 Feb;16(1):259-65. doi: 10.1007/s00784-010-0487-6. Epub 2010 Dec 7.
Periodontitis may affect atherosclerosis via the chronic inflammation. We investigated high-sensitivity C-reactive protein (hsCRP) in relation to early vascular atherosclerotic changes in non-symptomatic subjects with and without long-term periodontitis. Carotid ultrasonography with calculation of common carotid artery intima-media area (cIMA) was performed, and hsCRP and atherosclerosis risk factors were analysed in randomly chosen 93 patients with periodontitis and 41 controls. The relationship between hsCRP, cIMA and atherosclerosis risk factors was evaluated with multiple logistic regression analysis. Women displayed lower hsCRP (p < 0.05) and higher serum HDL (p < 0.001) than men. In all patients with periodontitis, cIMA values were higher than in controls. Periodontitis appeared to be a major predictor for increased cIMA (odds ratio, 3.82; 95% confidence interval, 1.19-12.26). Neither of these factors was significantly associated with hsCRP which thus appeared not sensitive enough to be a marker for periodontitis or atherosclerosis. Hence, irrespective of low hsCRP levels, periodontitis appeared to increase the risk for atherosclerosis.
牙周炎可能通过慢性炎症影响动脉粥样硬化。我们研究了高敏 C 反应蛋白（hsCRP）与有无长期牙周炎的无症状患者早期血管动脉粥样硬化变化的关系。对随机选择的 93 例牙周炎患者和 41 例对照者进行颈动脉超声检查，并计算颈总动脉内膜中层厚度（cIMA），分析 hsCRP 和动脉粥样硬化危险因素。采用多元逻辑回归分析评估 hsCRP、cIMA 和动脉粥样硬化危险因素之间的关系。女性 hsCRP 低于男性（p<0.05），血清 HDL 高于男性（p<0.001）。所有牙周炎患者的 cIMA 值均高于对照组。牙周炎似乎是 cIMA 升高的主要预测因素（比值比，3.82；95%置信区间，1.19-12.26）。hsCRP 与这些因素均无显著相关性，因此不够敏感，不能作为牙周炎或动脉粥样硬化的标志物。因此，无论 hsCRP 水平如何，牙周炎似乎都会增加动脉粥样硬化的风险。
