茶籽饼（Camellia oleifera Abel）中一种新的甾体皂苷及其对 PC12 细胞的保护作用。
A new saponin from tea seed pomace (Camellia oleifera Abel) and its protective effect on PC12 cells.
机构信息
Key Laboratory of Tea Biochemistry & Biotechnology, Ministry of Education and Ministry of Agriculture, Anhui Agricultural University, Hefei 230036, China.
出版信息
Molecules. 2012 Oct 1;17(10):11721-8. doi: 10.3390/molecules171011721.
A new triterpenoid saponin, oleiferasaponin A₁, was isolated from tea seed pomace (Camellia oleifera Abel). The structure of oleiferasaponin A₁ was elucidated on the basis of chemical and physicochemical evidence and was found to be 22-O-cis-2-hexenoyl-A₁-barrigenol 3-O-[β-D-galactopyranosyl(1→2)] [β-D-glucopyranosyl(1→2)-α-L-arabinopyranosyl(1→3)]-β-D-glucopyranosiduronic acid. PC12 cells injured with H₂O₂ were used as the model to test the protective effects of oleiferasaponin A₁. The results indicated that oleiferasaponin A₁ can potentially prevent the H₂O₂-induced cell death of PC12 cells.
从茶籽饼（Camellia oleifera Abel）中分离得到一种新的三萜皂苷，命名为油茶皂苷 A₁。根据化学和物理化学证据，阐明了油茶皂苷 A₁的结构，确定为 22-O-顺-2-己烯酰基-A₁-巴里根醇 3-O-[β-D-半乳糖吡喃糖苷(1→2)] [β-D-葡萄糖吡喃糖苷(1→2)-α-L-阿拉伯吡喃糖苷(1→3)]-β-D-葡萄糖醛酸。以过氧化氢（H₂O₂）损伤的 PC12 细胞为模型，考察油茶皂苷 A₁的保护作用。结果表明，油茶皂苷 A₁可能具有预防 PC12 细胞过氧化氢诱导死亡的作用。
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