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白对虾（Litopenaeus vannamei）脂质提取物的抗突变和抗增殖研究。

Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei).

机构信息

Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico.

出版信息

Mar Drugs. 2010 Nov 8;8(11):2795-809. doi: 10.3390/md8112795.

DOI:10.3390/md8112795
PMID:21139845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2996177/
Abstract

An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B(1), showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB(1) and proliferation of a cancer cell line.

摘要

从新鲜对虾（凡纳滨对虾）中提取的有机提取物，分别使用含有代谢激活物（S9）的鼠伤寒沙门氏菌测试菌株 TA98 和 TA100 以及癌细胞系（B 细胞淋巴瘤）研究其抗诱变和抗增殖特性。虾提取物通过薄层层析（TLC）进行顺序分段，并且对每个片段进行抗诱变和抗增殖活性测试。从虾中获得的粗有机提取物减少了黄曲霉毒素 B(1)引起的回复突变数，显示出剂量反应关系。活性提取物的连续 TLC 分段产生了几个具有抗突变和/或抗增殖活性的片段。这些结果表明，所测试物种的脂质部分含有具有化学保护特性的化合物，可降低 AFB(1)的致突变性和癌细胞系的增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/82974146c125/marinedrugs-08-02795f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/5e60411e9c49/marinedrugs-08-02795f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/4f7b45a2fdd7/marinedrugs-08-02795f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/9ae292dbeb3d/marinedrugs-08-02795f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/cea53054e242/marinedrugs-08-02795f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/3b666520d779/marinedrugs-08-02795f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/0d29291cab76/marinedrugs-08-02795f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/a2b70b007cec/marinedrugs-08-02795f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/82974146c125/marinedrugs-08-02795f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/5e60411e9c49/marinedrugs-08-02795f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/4f7b45a2fdd7/marinedrugs-08-02795f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/9ae292dbeb3d/marinedrugs-08-02795f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/cea53054e242/marinedrugs-08-02795f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/3b666520d779/marinedrugs-08-02795f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/0d29291cab76/marinedrugs-08-02795f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/a2b70b007cec/marinedrugs-08-02795f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e868/2996177/82974146c125/marinedrugs-08-02795f8.jpg

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