Yang Y J, Lee S H, Hong S J, Chung B C
Bioanalysis & Biotransformation Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
Clin Biochem. 1999 Aug;32(6):405-9. doi: 10.1016/s0009-9120(99)00036-3.
The role of dietary fatty acids (FAs) in benign and malignant prostatic diseases was investigated by comparing the composition value of serum fatty acids in the normal controls, and patients with prostate cancer (PC) and benign prostatic hyperplasia (BPH). Also, to estimate a possible association between PC risk and PUFAs, omega-3, omega-6 and omega-3/omega-6 FA composition ratios were compared among these groups.
Serum samples were obtained from 24 BPH and 19 PC patients, and from 21 age-matched normal male subjects. The serum concentration of 21 fatty acids was determined using gas chromatography/mass spectrometry.
The proportional values of saturated fatty acids (SFAs) groups demonstrated no specific difference between the control subjects and the patients. In the polyunsaturated fatty acids (PUFAs), we found that the omega-3 PUFAs level was significantly decreased in patient with BPH and PC and that the omega-6 PUFAs level was increased in PC only. The ratio of omega-3/omega-6 PUFAs decreased in the following order of normal, BPH, and PC.
It was proposed that the changed composition level of PUFAs including omega-3 and omega-6 PUFAs have certain relationship with both prostatic diseases. Therefore, the ratio of omega-3/omega-6 PUFAs also may have an important association with the benign and malignant status of prostatic disease.
通过比较正常对照组、前列腺癌（PC）患者和良性前列腺增生（BPH）患者血清脂肪酸的组成值，研究膳食脂肪酸（FAs）在良性和恶性前列腺疾病中的作用。此外，为评估PC风险与多不饱和脂肪酸（PUFAs）、ω-3、ω-6以及ω-3/ω-6脂肪酸组成比例之间的可能关联，对这些组进行了比较。
采集了24例BPH患者、19例PC患者以及21名年龄匹配的正常男性受试者的血清样本。使用气相色谱/质谱法测定21种脂肪酸的血清浓度。
饱和脂肪酸（SFAs）组的比例值在对照组和患者之间未显示出特定差异。在多不饱和脂肪酸（PUFAs）方面，我们发现BPH和PC患者的ω-3多不饱和脂肪酸水平显著降低，而仅PC患者的ω-6多不饱和脂肪酸水平升高。ω-3/ω-6多不饱和脂肪酸的比例按正常、BPH和PC的顺序降低。
有人提出，包括ω-3和ω-6多不饱和脂肪酸在内的多不饱和脂肪酸组成水平的变化与前列腺疾病均有一定关系。因此，ω-3/ω-6多不饱和脂肪酸的比例也可能与前列腺疾病的良性和恶性状态有重要关联。
