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来自章鱼（Paraoctopus limaculatus）的生物活性脂质提取物：抗诱变和抗增殖研究。

Bioactive Lipidic Extracts from Octopus (Paraoctopus limaculatus): Antimutagenicity and Antiproliferative Studies.

机构信息

Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, 83000 Hermosillo, SON, Mexico.

出版信息

Evid Based Complement Alternat Med. 2013;2013:273582. doi: 10.1155/2013/273582. Epub 2013 Jan 16.

DOI:10.1155/2013/273582
PMID:23401709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3562661/
Abstract

Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using thin layer chromatography (TLC), and each fraction was tested for antimutagenic and antiproliferative activities. Organic extract reduced the number of revertants caused by aflatoxin B(1) showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. Based on the results obtained, the isolated fractions obtained from octopus contain compounds with chemoprotective properties that reduce the mutagenicity of AFB(1) and proliferation of cancer cell lines.

摘要

从新鲜章鱼（Paraoctopus limaculatus）的有机提取物中分离得到的馏分，分别使用带有代谢激活（S9）的沙门氏菌测试菌株 TA98 和 TA100 以及癌细胞系（B 细胞淋巴瘤）研究了其生物活性，如抗诱变和抗增殖特性。从章鱼触手中获得的氯仿提取物，采用薄层色谱（TLC）进行顺序分段，对每个馏分进行抗诱变和抗增殖活性测试。有机提取物减少了黄曲霉毒素 B(1)引起的回复突变数，表现出剂量反应关系的类型。活性提取物的连续 TLC 分段产生了几种具有抗突变和/或抗增殖作用的馏分。根据获得的结果，从章鱼中分离得到的分离物含有具有化学保护特性的化合物，可降低 AFB(1)的致突变性和癌细胞系的增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/5b7b5f9a1eaf/ECAM2013-273582.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/27397ee3c72d/ECAM2013-273582.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/25c88b048a7a/ECAM2013-273582.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/475df1222942/ECAM2013-273582.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/37ed89203aff/ECAM2013-273582.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/0605ddd20283/ECAM2013-273582.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/78ec113ab8fd/ECAM2013-273582.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/5b7b5f9a1eaf/ECAM2013-273582.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/27397ee3c72d/ECAM2013-273582.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/25c88b048a7a/ECAM2013-273582.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/475df1222942/ECAM2013-273582.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/37ed89203aff/ECAM2013-273582.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/0605ddd20283/ECAM2013-273582.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/78ec113ab8fd/ECAM2013-273582.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a133/3562661/5b7b5f9a1eaf/ECAM2013-273582.007.jpg

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