Corey L, Reeves W C, Holmes K K
N Engl J Med. 1978 Nov 2;299(18):986-91. doi: 10.1056/NEJM197811022991805.
We studied the relations between the cellular immune response, pre-existing complement-fixing antibody and virus type with duration of virus excretion in genital herpes simplex virus (HSV) infection. Thirty-six patients (seven with HSV-1 and 29 with HSV-2) with genital herpes underwent serologic testing, sequential viral cultures and weekly determination of lymphocyte-transformation stimulation index with inactivated HSV antic n. The duration of virus excretion was shortest in those with pre-existing complement-fixing antibody, was unrelated to virus type, and was inversely correlated with the magnitude of the mean peak stimulation index (r = -0.69, P less than 0.001). Prolonged virus excretion occurred in patients with a delayed and diminished peak index. Recurrent episodes had a higher peak index (29.4 compared to 14.5) (P less than 0.02), an earlier development of the peak during recurrences (9.1 vs. 25.8 days) (P less than 0.01) and a briefer duration of viral shedding than initial episodes. Thus, the temporal course and magnitude of the stimulation index correlate with and may determine the duration of genital HSV infection.
我们研究了细胞免疫反应、预先存在的补体结合抗体、病毒类型与单纯疱疹病毒（HSV）生殖器感染中病毒排出持续时间之间的关系。36例生殖器疱疹患者（7例为HSV - 1感染，29例为HSV - 2感染）接受了血清学检测、连续病毒培养以及每周用灭活的HSV抗原测定淋巴细胞转化刺激指数。有预先存在补体结合抗体的患者病毒排出持续时间最短，与病毒类型无关，且与平均峰值刺激指数的大小呈负相关（r = -0.69，P < 0.001）。峰值指数延迟和降低的患者出现病毒排出时间延长。复发发作的峰值指数更高（分别为29.4和14.5）（P < 0.02），复发时峰值出现更早（分别为9.1天和25.8天）（P < 0.01），且病毒脱落持续时间比初次发作更短。因此，刺激指数的时间进程和大小与生殖器HSV感染的持续时间相关，并且可能决定其持续时间。
