Duke University Medical Center, Durham, North Carolina 27710, USA.
Oncology (Williston Park). 2010 Nov 15;24(12):1149-55.
Modern cancer care is characterized by a focus on organ-sparing multi-modal treatments. In the case of non-muscle-invasive bladder cancer this is particularly true; treatment is focused on reducing the frequency of low-risk recurrences and preventing high-risk progression. Deep regional hyperthermia is an oncologic therapeutic modality that can help achieve these two goals. The combination of hyperthermia with chemotherapy and radiotherapy has improved patient outcomes in several tumor types. In this review, we highlight the biology of therapeutic fever-range hyperthermia, discuss how hyperthermia is administered and dosed, demonstrate how heat can be added to other treatment regimens, and summarize the data supporting the role of hyperthermia in the management of bladder cancer.
现代癌症治疗的特点是注重器官保留的多模式治疗。在非肌肉浸润性膀胱癌的情况下更是如此；治疗的重点是降低低危复发的频率并预防高危进展。深部区域性热疗是一种肿瘤治疗方式，可以帮助实现这两个目标。热疗与化疗和放疗相结合，已经改善了多种肿瘤类型患者的预后。在这篇综述中，我们强调了治疗性发热范围热疗的生物学特性，讨论了热疗的实施和剂量，展示了如何将热量添加到其他治疗方案中，并总结了支持热疗在膀胱癌治疗中的作用的数据。
