van der Heijden Antoine G, Dewhirst Mark W
a Department of Urology , Radboud University Medical Centre , Nijmegen , the Netherlands ;
b Radiation Oncology, Duke University , Durham , North Carolina , USA.
Int J Hyperthermia. 2016 Jun;32(4):434-45. doi: 10.3109/02656736.2016.1155761. Epub 2016 Apr 20.
Non-muscle-invasive bladder cancer is a challenging disease, even given its superficial nature. It is prone to multiple recurrences and progression to muscle-invasive cancer. These features of this disease contribute significantly to reduced quality of life as well as creating significant morbidity and even mortality. Randomised trials demonstrate that when hyperthermia is added to conventional mitomycin-C treatment that local control rates and progression-free survival are substantially improved. In this review we consider how hyperthermia can exert such beneficial effects. Some of the mechanisms presented are theoretical, while others are facts. It is hoped that this review will contribute rationale for further examination of mechanisms, because an understanding of such mechanisms may lead to even better chemotherapeutic approaches, as well as potential biomarkers for predicting and monitoring treatment success.
非肌层浸润性膀胱癌是一种具有挑战性的疾病，即便其本质上是表浅性的。它易于多次复发并进展为肌层浸润性癌。该疾病的这些特征显著降低了生活质量，还造成了严重的发病率甚至死亡率。随机试验表明，在传统丝裂霉素-C治疗中加入热疗后，局部控制率和无进展生存期得到了显著改善。在本综述中，我们探讨热疗如何发挥这种有益作用。所提出的一些机制是理论性的，而其他一些则是事实。希望本综述能为进一步研究机制提供理论依据，因为了解这些机制可能会带来更好的化疗方法，以及预测和监测治疗成功的潜在生物标志物。
