半胱氨酸激活的硫化氢 (H2S) 供体。
Cysteine-activated hydrogen sulfide (H2S) donors.
机构信息
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
出版信息
J Am Chem Soc. 2011 Jan 12;133(1):15-7. doi: 10.1021/ja1085723. Epub 2010 Dec 10.
Abstract
H(2)S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H(2)S has been hindered by the lack of controllable H(2)S donors that could mimic the slow and continuous H(2)S generation process in vivo. Herein we report a series of cysteine-activated H(2)S donors. Structural modifications of these molecules can regulate the rates of H(2)S generation. These compounds can be useful tools in H(2)S research.
摘要
H2S，一种新发现的气体信号分子，在生物系统中发挥着重要作用。然而，由于缺乏能够模拟体内 H2S 缓慢而持续产生过程的可控 H2S 供体，H2S 的研究受到了阻碍。在此，我们报告了一系列半胱氨酸激活的 H2S 供体。这些分子的结构修饰可以调节 H2S 的生成速率。这些化合物将是 H2S 研究的有用工具。
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