Center for Reproductive Health, Institute of Mother and Child, Warsaw, Poland.
Gynecol Endocrinol. 2011 Oct;27(10):849-56. doi: 10.3109/09513590.2010.538095. Epub 2010 Dec 10.
To investigate compliance, satisfaction, and preference in women using a transdermal contraceptive patch.
Women (18-46 years) from eight European countries used contraceptive patches (norelgestromin 6 mg, ethinylestradiol 600 μg) for six, 4-week treatment cycles. Compliance, satisfaction, and preference were assessed after 3 and 6 cycles and study completion using self-report methods.
Of the 778 participants, 36.8% (n = 287) used no contraception at baseline. The most common methods were oral contraceptives (67.9%, n = 334) and barrier methods (21.5%, n = 106). Of oral contraception users, 63.5% (n = 212) were satisfied or very satisfied with their previous method, but compliance was poor with 77.8% (n = 260) reporting missed doses. After 3 and 6 cycles, >80% of all included women were satisfied or very satisfied with the patch. At study completion, most participants (73.7%) reported a preference for the patch compared to their previous method. Of 4107 cycles, 3718 (90.5%) were completed with perfect compliance. Two pregnancies occurred during this study, representing a Pearl Index of 0.63. No new safety issues were identified and the patch was well tolerated.
Women were highly satisfied with transdermal contraception and preferred this form of family planning over their previous method. Transdermal contraception represents a valuable addition to contraceptive options with potential to offer high compliance and efficacy.
调查使用透皮避孕贴的女性的依从性、满意度和偏好。
来自 8 个欧洲国家的女性（18-46 岁）使用避孕贴（炔诺孕酮 6mg，炔雌醇 600μg）进行了 6 个 4 周的治疗周期。使用自我报告的方法在第 3 和第 6 个周期以及研究结束后评估依从性、满意度和偏好。
在 778 名参与者中，36.8%（n=287）在基线时没有使用任何避孕方法。最常见的方法是口服避孕药（67.9%，n=334）和屏障法（21.5%，n=106）。在口服避孕药使用者中，63.5%（n=212）对其之前的方法感到满意或非常满意，但依从性很差，77.8%（n=260）报告漏服。在第 3 和第 6 个周期后，超过 80%的所有纳入女性对贴片感到满意或非常满意。在研究结束时，大多数参与者（73.7%）表示更喜欢贴片而不是之前的方法。在 4107 个周期中，有 3718 个（90.5%）周期完全符合依从性要求。在这项研究期间发生了两例妊娠，妊娠率为 0.63。没有发现新的安全问题，贴片耐受良好。
女性对透皮避孕非常满意，并且更喜欢这种形式的计划生育方法而不是之前的方法。透皮避孕是一种有价值的避孕方法选择，具有提供高依从性和疗效的潜力。
