Institute of Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany.
Expert Rev Proteomics. 2010 Dec;7(6):927-41. doi: 10.1586/epr.10.83.
MALDI imaging mass spectrometry ('MALDI imaging') is an increasingly recognized technique for biomarker research. After years of method development in the scientific community, the technique is now increasingly applied in clinical research. In this article, we discuss the use of MALDI imaging in clinical proteomics and put it in context with classical proteomics techniques. We also highlight a number of upcoming challenges for personalized medicine, development of targeted therapies and diagnostic molecular pathology where MALDI imaging could help.
基质辅助激光解析电离成像质谱（MALDI 成像）是一种日益受到认可的生物标志物研究技术。经过多年的科学研究方法开发，该技术现已越来越多地应用于临床研究。本文讨论了 MALDI 成像在临床蛋白质组学中的应用，并将其与经典蛋白质组学技术进行了比较。我们还强调了一些即将面临的挑战，例如个性化医学、靶向治疗的发展和诊断分子病理学，在这些领域中 MALDI 成像可能会有所帮助。
