Department of Psychiatry, Chung Ang University, College of Medicine, Seoul, Korea.
Cyberpsychol Behav Soc Netw. 2010 Dec;13(6):655-61. doi: 10.1089/cyber.2009.0327. Epub 2010 May 11.
Brain responses, particularly within the orbitofrontal and cingulate cortices, to Internet video-game cues in college students are similar to those observed in patients with substance dependence in response to the substance-related cues. In this study, we report changes in brain activity between baseline and following 6 weeks of Internet video-game play. We hypothesized that subjects with high levels of self-reported craving for Internet video-game play would be associated with increased activity in the prefrontal cortex, particularly the orbitofrontal and anterior cingulate cortex. Twenty-one healthy university students were recruited. At baseline and after a 6-week period of Internet video-game play, brain activity during presentation of video-game cues was assessed using 3T blood oxygen level dependent functional magnetic resonance imaging. Craving for Internet video-game play was assessed by self-report on a 7-point visual analogue scale following cue presentation. During a standardized 6-week video-game play period, brain activity in the anterior cingulate and orbitofrontal cortex of the excessive Internet game-playing group (EIGP) increased in response to Internet video-game cues. In contrast, activity observed in the general player group (GP) was not changed or decreased. In addition, the change of craving for Internet video games was positively correlated with the change in activity of the anterior cingulate in all subjects. These changes in frontal-lobe activity with extended video-game play may be similar to those observed during the early stages of addiction.
大脑对大学生网络视频游戏线索的反应，特别是眶额皮质和扣带皮质的反应，与物质依赖患者对物质相关线索的反应相似。在这项研究中，我们报告了在基线和 6 周的网络视频游戏后大脑活动的变化。我们假设自我报告的对网络视频游戏的强烈渴望的受试者与前额叶皮层（特别是眶额和前扣带皮质）的活动增加有关。我们招募了 21 名健康的大学生。在基线和 6 周的网络视频游戏后，使用 3T 血氧水平依赖功能磁共振成像评估了视频游戏线索呈现时的大脑活动。在线索呈现后，通过 7 分制视觉模拟量表评估对网络视频游戏的渴望程度。在标准化的 6 周视频游戏期间，过度网络游戏组（EIGP）的前扣带和眶额皮质对网络视频游戏线索的反应中大脑活动增加。相比之下，普通玩家组（GP）的活动没有变化或减少。此外，所有受试者的前扣带活动变化与对网络视频游戏的渴望变化呈正相关。这种随着视频游戏时间的延长而导致的额叶活动的变化可能与成瘾早期观察到的变化相似。
