Huszczuk A, Whipp B J, Wasserman K
Dept of Medicine, Harbor-UCLA Medical Center, Torrance 90509.
Eur Respir J. 1990 Apr;3(4):465-8.
We have developed a method for simulating respiratory gas exchange for on-line calibration of metabolic measurement systems. It utilizes a pump which intakes a mixture of atmospheric air and a known flow of precision-analysed calibration gas (21% CO2, 79% N2). It expels the resulting mixture with flow wave form and profiles of gas concentration which closely resemble those of normal expiration. Control of the calibration mixture's inflow allows the investigator to set any desired metabolic rate regardless of the minute ventilatory rate. This separation of metabolic from ventilatory rates provides a stringent test of the computational performance of the respiratory gas exchange measurement systems. The apparatus can reproduce any range of respiratory and metabolic performance (currently ranging from 0.2-5 l.min-1 O2 uptake and CO2 output) with accuracy +/- 2%.
我们开发了一种用于模拟呼吸气体交换的方法，以对代谢测量系统进行在线校准。它使用一个泵，该泵吸入大气和已知流量的经过精确分析的校准气体（21%二氧化碳，79%氮气）的混合物。它以与正常呼气非常相似的气流波形和气体浓度曲线排出所得混合物。校准混合物流入量的控制使研究人员能够设定任何所需的代谢率，而不管分钟通气率如何。代谢率与通气率的这种分离对呼吸气体交换测量系统的计算性能提供了严格的测试。该装置能够以±2%的精度再现任何范围的呼吸和代谢性能（目前范围为0.2 - 5升·分钟⁻¹的氧气摄取量和二氧化碳排出量）。
