Murata A, Ogawa M, Yasuda T, Nishijima J, Oka Y, Ohmachi Y, Hiraoka N, Niinobu T, Uda K, Mori T
Second Department of Surgery, Osaka University Medical School, Japan.
Immunol Invest. 1990 Jun;19(3):271-8. doi: 10.3109/08820139009041842.
We measured serum immunoreactive interleukin 6 (IL-6) levels in patients after major thoraco-abdominal surgery and compared them with changes in serum C-reactive protein (CRP) and pancreatic secretory trypsin inhibitor (PSTI) levels. Serum IL-6 levels were elevated earlier than serum CRP or PSTI. There were significant relationships between the peak levels of serum IL-6 and the operation time (p less than 0.05) or the volume of blood loss during surgery (p less than 0.05), showing that serum IL-6 can be a useful laboratory test for the evaluation of tissue injuries due to surgical intervention. Though there was a significant relationship between the peak levels of IL-6 and CRP (p less than 0.01), there was no relationship between the peak levels of IL-6 and PSTI.
我们检测了接受胸腹联合大手术后患者血清中免疫反应性白细胞介素6（IL-6）水平，并将其与血清C反应蛋白（CRP）和胰腺分泌性胰蛋白酶抑制剂（PSTI）水平的变化进行比较。血清IL-6水平升高早于血清CRP或PSTI。血清IL-6峰值水平与手术时间（p<0.05）或手术期间失血量（p<0.05）之间存在显著相关性，表明血清IL-6可作为评估手术干预所致组织损伤的有用实验室检测指标。虽然IL-6峰值水平与CRP之间存在显著相关性（p<0.01），但IL-6峰值水平与PSTI之间无相关性。
