Quinti I, Velardi A, Le Moli S, Guerra E, D'Amelio R, Mastrantonio P, Martelli M F, Aiuti F
Department of Allergy and Clinical Immunology, University of Rome, Italy.
J Clin Immunol. 1990 May;10(3):160-6. doi: 10.1007/BF00917916.
Allogeneic bone marrow-engrafted adults immunized with meningococcal types A and C and pneumococcal type 14 polysaccharide antigens showed only low antibody titers of the IgM class, no antibody titers of the IgG or IgA classes, and no bactericidal activity in vitro. The analytical isoelectrofocusing showed the appearance of a restricted pattern of clonotypes in a minority of subjects. These observations are consistent with the hypothesis that B cells in bone marrow transplant patients express some characteristics of neonatal B cells and suggest that polysaccharide-protein conjugates, rather than isolated polysaccharide, might be utilized in the setting of bone marrow transplantation.
用A群和C群脑膜炎球菌及14价肺炎球菌多糖抗原免疫的同种异体骨髓移植成年受者，仅表现出低水平的IgM类抗体滴度，未检测到IgG或IgA类抗体滴度，且体外无杀菌活性。分析性等电聚焦显示少数受试者出现克隆型受限模式。这些观察结果与骨髓移植患者的B细胞表现出新生儿B细胞某些特征的假设一致，并提示在骨髓移植情况下可能应使用多糖-蛋白结合物而非单纯的多糖。
