从 Thom 青霉（Penicillium crustosum Thom.）中分离得到 secopenitrem D，一种吲哚生物碱，并对其结构进行了阐明。

Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom.

机构信息

Section of Chemistry and Toxicology, National Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway.

出版信息

Toxicon. 2011 Feb;57(2):259-65. doi: 10.1016/j.toxicon.2010.11.020. Epub 2010 Dec 8.

DOI:10.1016/j.toxicon.2010.11.020

Abstract

Chemical investigation of three isolates of Penicillium crustosum Thom cultures, one of which was derived from a recent dog poisoning investigation, has led to the isolation and structure elucidation of secopenitrem D (1). Penitrems A-F and roquefortine C were also present in the isolates analyzed. The structure of 1 was unambiguously assigned based on extensive 1D and 2D-NMR spectroscopic experiments, MS-aided structural studies and by comparison with structurally related congeners. Secopenitrem D lacks the C-16-C-18 ether linkage present in penitrems A-F.

摘要

从近期的一起犬类中毒调查中分离得到的三株 Penicillium crustosum Thom 培养物的化学研究，导致了 secopenitrem D（1）的分离和结构阐明。在所分析的培养物中还存在 penitrems A-F 和 roquefortine C。1 的结构是基于广泛的 1D 和 2D-NMR 波谱实验、MS 辅助结构研究以及与结构相关的同系物比较而明确确定的。Secopenitrem D 缺乏 penitrems A-F 中存在的 C-16-C-18 醚键。