Section of Chemistry and Toxicology, National Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway.
Toxicon. 2011 Feb;57(2):259-65. doi: 10.1016/j.toxicon.2010.11.020. Epub 2010 Dec 8.
Chemical investigation of three isolates of Penicillium crustosum Thom cultures, one of which was derived from a recent dog poisoning investigation, has led to the isolation and structure elucidation of secopenitrem D (1). Penitrems A-F and roquefortine C were also present in the isolates analyzed. The structure of 1 was unambiguously assigned based on extensive 1D and 2D-NMR spectroscopic experiments, MS-aided structural studies and by comparison with structurally related congeners. Secopenitrem D lacks the C-16-C-18 ether linkage present in penitrems A-F.
从近期的一起犬类中毒调查中分离得到的三株 Penicillium crustosum Thom 培养物的化学研究，导致了 secopenitrem D（1）的分离和结构阐明。在所分析的培养物中还存在 penitrems A-F 和 roquefortine C。1 的结构是基于广泛的 1D 和 2D-NMR 波谱实验、MS 辅助结构研究以及与结构相关的同系物比较而明确确定的。Secopenitrem D 缺乏 penitrems A-F 中存在的 C-16-C-18 醚键。
