黄曲霉毒素B1注射后猴子及其F1代骨髓中染色体畸变的频率。
Frequency of chromosome aberrations in bone marrow of monkeys and their F1 after aflatoxin B1 injection.
作者信息
Adgigitov F I, Kosichenko L P, Popandopulo P G, Gubeladze D A, Djemilev Z A
出版信息
Exp Pathol. 1984;26(3):163-9. doi: 10.1016/s0232-1513(84)80044-4.
A mutagenic effect of aflatoxin B1 (AFB1) in somatic cells of primates is investigated. It is shown that AFB1 elevated the frequency of chromosome aberrations in the bone marrow of two species of monkeys: Macaca mulatta and Papio hamadryas. Beside chromosome aberrations, genome mutations were found in these experimental primates. AFB1-induced chromosome aberrations were constantly revealed during two years of study. Increase in the frequency of chromosome aberrations could be demonstrated in Macaca babies born from females that had received AFB1 at the final stage of pregnancy.
研究了黄曲霉毒素B1（AFB1）对灵长类动物体细胞的诱变作用。结果表明，AFB1提高了两种猴子（猕猴和阿拉伯狒狒）骨髓中染色体畸变的频率。除了染色体畸变外，在这些实验灵长类动物中还发现了基因组突变。在两年的研究中，不断发现AFB1诱导的染色体畸变。在孕期最后阶段接受AFB1的雌性所生的猕猴幼崽中，可以证明染色体畸变频率增加。
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