膜泡形成。
Membrane budding.
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA.
出版信息
Cell. 2010 Dec 10;143(6):875-87. doi: 10.1016/j.cell.2010.11.030.
Abstract
Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and enveloped virus release. These events range from those that are primarily protein driven, such as the formation of coated vesicles, to those that are primarily lipid driven, such as microdomain-dependent biogenesis of multivesicular bodies. Other types of budding reside in the middle of this spectrum, including caveolae biogenesis, HIV-1 budding, and ESCRT-catalyzed multivesicular body formation. Some of these latter events involve budding away from cytosol, and this unusual topology involves unique mechanisms. This Review discusses progress toward understanding the structural and energetic bases of these different membrane-budding paradigms.
摘要
膜出芽是囊泡运输、多泡体生物发生和包膜病毒释放的关键步骤。这些事件的范围从主要由蛋白质驱动的事件（如形成有被小泡）到主要由脂质驱动的事件（如微域依赖性多泡体生物发生）不等。其他类型的出芽位于该谱的中间，包括 caveolae 生物发生、HIV-1 出芽和 ESCRT 催化的多泡体形成。其中一些后期事件涉及远离细胞质的出芽，这种不寻常的拓扑结构涉及独特的机制。本综述讨论了在理解这些不同的膜出芽范例的结构和能量基础方面取得的进展。
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