接受抗雌激素药物治疗的乳腺癌患者在接受针灸治疗 2 年后的生活质量：一项定性研究。
Quality of life of breast cancer patients medicated with anti-estrogens, 2 years after acupuncture treatment: a qualitative study.
机构信息
Pain Clinic, Vestfold Hospital, Tønsberg, Norway.
出版信息
Int J Womens Health. 2010 Sep 28;2:319-25. doi: 10.2147/IJWH.S12809.
OBJECTIVE
The aim of this study was to examine the quality of life of breast cancer patients medicated with estrogen antagonists, 2 years after having acupuncture treatment for hot flashes.
METHODS AND MATERIALS
Our sample was taken from women who had recently participated in a randomized controlled trial investigating the effects of acupuncture on hot flashes, a side effect of estrogen-antagonist treatment. Forty-one women from the true acupuncture treatment group and 41 women from the control group (sham acupuncture), who had 2 years previously received a course of 15 acupuncture treatments over a period of 10 weeks, were asked to answer an open question. The question, "Would you like to share your thoughts and experiences related to your breast cancer diagnosis, treatments or anything else?" was by being open, broad, and nonspecific, intended to stimulate subjective information, which was not included in the original, or future quantitative studies. Qualitative data were analyzed using systematic text condensation.
RESULTS
Most women were troubled by two or more side effects due to anti-estrogen medication, negatively affecting their life quality. Symptoms included hot flashes, sleep problems, muscle and joint pain, arm edema, fatigue, weight gain, depression, and lack of sexual desire. Women previously treated with sham acupuncture complained that hot flashes were still problematic, whilst those previously treated with traditional Chinese acupuncture found them less of a problem and generally had a more positive outlook on life. These results compare favorably with the findings from our original study that measured quantitatively health related quality of life.
CONCLUSION
Side effects due to anti-estrogen treatment seriously affect the quality of life of breast cancer operated patients. Patients who had previously been treated with traditional Chinese acupuncture complained less of hot flashes, and had a more positive outlook on life, than women who had previously been treated with sham acupuncture.
目的
本研究旨在探讨接受雌激素拮抗剂治疗的乳腺癌患者在接受针刺治疗热潮红 2 年后的生活质量。
方法和材料
我们的样本取自最近参加一项针刺治疗热潮红（雌激素拮抗剂治疗的副作用）效果随机对照试验的女性。41 名来自真正针刺治疗组和 41 名来自对照组（假针刺）的女性，她们在 2 年前接受了为期 10 周的 15 次针刺治疗，被要求回答一个开放式问题。这个问题是：“你愿意分享你与乳腺癌诊断、治疗或其他任何事情相关的想法和经验吗？”通过开放性、广泛性和非特异性，旨在激发主观信息，这些信息不包括在原始或未来的定量研究中。定性数据采用系统文本浓缩法进行分析。
结果
大多数女性因抗雌激素药物而出现两种或两种以上的副作用，对生活质量产生负面影响。症状包括热潮红、睡眠问题、肌肉和关节疼痛、手臂肿胀、疲劳、体重增加、抑郁和缺乏性欲。之前接受假针刺治疗的女性抱怨热潮红仍然是个问题，而之前接受传统中医针刺治疗的女性则认为热潮红问题较少，对生活的总体看法更为积极。这些结果与我们原始研究中定量测量健康相关生活质量的结果相吻合。
结论
抗雌激素治疗引起的副作用严重影响了接受过乳腺癌手术的患者的生活质量。与之前接受过假针刺治疗的女性相比，之前接受过传统中医针刺治疗的女性抱怨热潮红的次数较少，对生活的总体看法更为积极。
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