Allende Daniela S, Drake Richard D, Chen Longwen
Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA.
Patholog Res Int. 2010 Apr 13;2010:438534. doi: 10.4061/2010/438534.
Mural nodules of ovarian mucinous borderline tumors are rare. In this study, we report a case of mural nodules of clear cell carcinoma in an intestinal type mucinous borderline tumor of the ovary. The patient was a 54-years-old woman presented with back and pelvic pain for 3 months. A right-sided multiloculated ovarian mass approximately 20 cm was identified on the CT scan. CA-125 was moderately elevated. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and bilateral pelvic and para-aortic lymphadenectomy. Grossly, the right ovarian mass showed a multiloculated cystic mass with mucinous fluid. There were papillations in the internal surface and two mural nodules were seen. Microscopic examination revealed that the cystic mass was an intestinal type borderline mucinous tumor. The mural nodules showed a classic histology of clear cell carcinoma with tubulocystic and papillary growth patterns. This is an extremely rare case of mural nodules of clear cell carcinoma arising in a mucinous borderline tumor.
卵巢黏液性交界性肿瘤的壁层结节罕见。在本研究中，我们报告1例卵巢肠型黏液性交界性肿瘤中出现透明细胞癌壁层结节的病例。患者为一名54岁女性，出现背部和盆腔疼痛3个月。CT扫描发现右侧卵巢有一个约20 cm的多房性肿块。CA - 125中度升高。她接受了全腹子宫切除术、双侧输卵管卵巢切除术以及双侧盆腔和腹主动脉旁淋巴结切除术。大体上，右侧卵巢肿块为一个含有黏液性液体的多房性囊性肿块。内表面有乳头状物，可见两个壁层结节。显微镜检查显示囊性肿块为肠型交界性黏液性肿瘤。壁层结节呈现透明细胞癌的经典组织学表现，具有微囊状和乳头状生长模式。这是1例极其罕见的在黏液性交界性肿瘤中出现透明细胞癌壁层结节的病例。
