Department of Clinical Laboratory, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
PLoS One. 2010 Dec 3;5(12):e15113. doi: 10.1371/journal.pone.0015113.
The transcription profile of chipmunk parvovirus (ChpPV), a tentative member of the genus Erythrovirus in the subfamily Parvovirinae of the family Parvoviridae, was characterized by transfecting a nearly full-length genome. We found that it is unique from the profiles of human parvovirus B19 and simian parvovirus, the members in the genus Erythrovirus so far characterized, in that the small RNA transcripts were not processed for encoding small non-structural proteins. However, like the large non-structural protein NS1 of the human parvovirus B19, the ChpPV NS1 is a potent inducer of apoptosis. Further phylogenetic analysis of ChpPV with other parvoviruses in the subfamily Parvovirinae indicates that ChpPV is distinct from the members in genus Erythrovirus. Thus, we conclude that ChpPV may represent a new genus in the family Parvoviridae.
花栗鼠细小病毒（ChpPV）的转录谱，暂定属于细小病毒科细小病毒亚科红病毒属，通过转染几乎全长基因组进行了特征描述。我们发现，与迄今为止特征明确的红病毒属成员，人类细小病毒 B19 和猴细小病毒相比，其小 RNA 转录物未被加工用于编码小非结构蛋白，这一点是独特的。然而，与人类细小病毒 B19 的大非结构蛋白 NS1 一样，ChpPV NS1 是一种有效的凋亡诱导剂。用细小病毒科细小病毒亚科中的其他细小病毒对 ChpPV 进行的进一步系统发育分析表明，ChpPV 与红病毒属的成员不同。因此，我们得出结论，ChpPV 可能代表细小病毒科中的一个新属。
