对双曲钩端螺旋体和流产布鲁氏菌抗体反应的抑制以及贝尼尔治疗后免疫抑制的恢复。
Suppression of antibody response to Leptospira biflexa and Brucella abortus and recovery from immunosuppression after Berenil treatment.
作者信息
Rurangirwa F R, Tabel H, Losos G J, Tizard I R
出版信息
Infect Immun. 1979 Dec;26(3):822-6. doi: 10.1128/iai.26.3.822-826.1979.
Abstract
Zebu cattle infected with either Trypanosoma congolense EATRO 1800 or Trypanosoma vivax EATRO 1721 had suppressed humoral immune responses to Leptospira biflexa injected intravenously and to attenuated Brucella abortus injected subcutaneously. T. congolense infections were more suppressive than T. vivax infections. In cattle infected with T. vivax, the suppression of immune responses to both bacterial immunogens was abrogated when the animals were treated with Berenil at the time of antigen administration. In cattle infected with T. congolense, simultaneous Berenil treatment at the time of vaccination abolished the suppression of immune response to L. biflexa, and lessened but did not abrogate the suppression of immune response to B. abortus.
摘要
感染刚果锥虫EATRO 1800或活泼锥虫EATRO 1721的瘤牛，对静脉注射的双曲钩端螺旋体和皮下注射的减毒流产布鲁氏菌的体液免疫反应受到抑制。刚果锥虫感染比活泼锥虫感染的抑制作用更强。在感染活泼锥虫的牛中，在给予抗原时用贝尼尔治疗，对两种细菌免疫原的免疫反应抑制作用被消除。在感染刚果锥虫的牛中，接种疫苗时同时使用贝尼尔治疗，消除了对双曲钩端螺旋体免疫反应的抑制作用，并减轻了但并未消除对流产布鲁氏菌免疫反应的抑制作用。
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