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Infect Immun. 1979 Dec;26(3):822-6. doi: 10.1128/iai.26.3.822-826.1979.
2
Hemolytic complement and serum C3 levels in Zebu cattle infected with Trypanosoma congolense and Trypanosoma vivax and the effect of trypanocidal treatment.感染刚果锥虫和活跃锥虫的瘤牛的溶血补体和血清C3水平以及杀锥虫治疗的效果。
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Berenil (diminazene aceturate)-resistant Trypanosoma congolense in cattle under natural tsetse challenge at Kibaha, Tanzania.在坦桑尼亚基巴哈自然采采蝇挑战下对牛体内耐贝尼尔（乙酰氨基阿脲）的刚果锥虫进行研究。
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Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection.二脒那嗪乙酰脲（贝尼尔）调节宿主细胞和炎症反应以抵抗冈比亚锥虫感染。
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The role of complement in the induction and regulation of immune responses.补体在免疫反应的诱导和调节中的作用。
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10
Suppressor factor of T-cell activation and decreased interleukin 2 activity in experimental African trypanosomiasis.实验性非洲锥虫病中T细胞激活抑制因子及白细胞介素2活性降低
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本文引用的文献

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Improved microtechnique for the leptospiral microscopic agglutination test.用于钩端螺旋体显微镜凝集试验的改良显微技术。
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Immunosuppressive effect of Trypanosoma congolense and Trypanosoma vivax on the secondary immune response of cattle to Mycoplasma mycoides subsp mycoides.刚果锥虫和活泼锥虫对牛针对丝状支原体丝状亚种的二次免疫反应的免疫抑制作用。
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Susceptibility of inbred strains of mice to Trypanosoma congolense: correlation with changes in spleen lymphocyte populations.近交系小鼠对刚果锥虫的易感性：与脾脏淋巴细胞群体变化的相关性。
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Suppressor cells and loss of B-cell potential in mice infected with Trypanosoma brucei.感染布氏锥虫的小鼠中的抑制细胞与B细胞潜能丧失
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Suppressor cells in experimentally trypanosomiasis.
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Immunosuppression in bovine trypanosomiasis: studies with louping-ill vaccine.牛锥虫病中的免疫抑制：用跳跃病疫苗进行的研究。
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对双曲钩端螺旋体和流产布鲁氏菌抗体反应的抑制以及贝尼尔治疗后免疫抑制的恢复。

Suppression of antibody response to Leptospira biflexa and Brucella abortus and recovery from immunosuppression after Berenil treatment.

作者信息

Rurangirwa F R, Tabel H, Losos G J, Tizard I R

出版信息

Infect Immun. 1979 Dec;26(3):822-6. doi: 10.1128/iai.26.3.822-826.1979.

DOI:10.1128/iai.26.3.822-826.1979
PMID:118933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414692/
Abstract

Zebu cattle infected with either Trypanosoma congolense EATRO 1800 or Trypanosoma vivax EATRO 1721 had suppressed humoral immune responses to Leptospira biflexa injected intravenously and to attenuated Brucella abortus injected subcutaneously. T. congolense infections were more suppressive than T. vivax infections. In cattle infected with T. vivax, the suppression of immune responses to both bacterial immunogens was abrogated when the animals were treated with Berenil at the time of antigen administration. In cattle infected with T. congolense, simultaneous Berenil treatment at the time of vaccination abolished the suppression of immune response to L. biflexa, and lessened but did not abrogate the suppression of immune response to B. abortus.

摘要

感染刚果锥虫EATRO 1800或活泼锥虫EATRO 1721的瘤牛，对静脉注射的双曲钩端螺旋体和皮下注射的减毒流产布鲁氏菌的体液免疫反应受到抑制。刚果锥虫感染比活泼锥虫感染的抑制作用更强。在感染活泼锥虫的牛中，在给予抗原时用贝尼尔治疗，对两种细菌免疫原的免疫反应抑制作用被消除。在感染刚果锥虫的牛中，接种疫苗时同时使用贝尼尔治疗，消除了对双曲钩端螺旋体免疫反应的抑制作用，并减轻了但并未消除对流产布鲁氏菌免疫反应的抑制作用。