Whitelaw D D, Scott J M, Reid H W, Holmes P H, Jennings F W, Urquhart G M
Res Vet Sci. 1979 Jan;26(1):102-7.
The antibody response to louping-ill virus vaccine was examined in mice infected with Trypanosoma brucei and T congolense, and in Ethiopian cattle experimentally infected with T brucei, T congolense and T vivax. In mice the antibody response was completely suppressed, while in cattle infected with T congolense and T vivax the antibody response to the vaccine was only 10 per cent that of uninfected animals. In contrast, the response of cattle infected with T brucei was not significantly reduced, and this was attributed to their relatively light and transient parasitaemias. Trypanocidal chemotherapy (diminazine aceturate) administered on the same day as vaccination largely restored the competence of the immune response of both mice and cattle infected with T congolense. The use of such drugs should be considered when cattle are vaccinated in trypanosome endemic areas.
在感染了布氏锥虫和刚果锥虫的小鼠以及实验感染了布氏锥虫、刚果锥虫和活泼锥虫的埃塞俄比亚牛中，检测了对跳跃病病毒疫苗的抗体反应。在小鼠中，抗体反应被完全抑制，而在感染刚果锥虫和活泼锥虫的牛中，对疫苗的抗体反应仅为未感染动物的10%。相比之下，感染布氏锥虫的牛的反应没有显著降低，这归因于它们相对较轻且短暂的寄生虫血症。在接种疫苗当天给予杀锥虫化疗药物（乙酰氨基苯脒），在很大程度上恢复了感染刚果锥虫的小鼠和牛的免疫反应能力。在锥虫流行地区给牛接种疫苗时，应考虑使用此类药物。
