Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brasil.
Braz J Med Biol Res. 2011 Jan;44(1):1-10. doi: 10.1590/s0100-879x2010007500141. Epub 2010 Dec 10.
A photodynamic effect occurs when photosensitiser molecules absorb light and dissipate the absorbed energy by transferring it to biological acceptors (usually oxygen), generating an excess of reactive species that are able to force cells into death pathways. Several tropical diseases present physiopathological aspects that are accessible to the application of a photosensitiser and local illumination. In addition, disease may be transmitted through infected blood donations, and many of the aetiological agents associated with tropical diseases have been shown to be susceptible to the photodynamic approach. However, there has been no systematic investigation of the application of photoantimicrobial agents in the various presentations, whether to human disease or to the disinfection of blood products or even as photo-insecticides. We aim in this review to report the advances in the photoantimicrobial approach that are beneficial to the field of anti-parasite therapy and also have the potential to facilitate the development of low-cost/high-efficiency protocols for underserved populations.
当光敏剂分子吸收光并通过将吸收的能量转移到生物受体（通常是氧气）来耗散吸收的能量时，就会发生光动力效应，从而产生过量的反应性物质，这些物质能够迫使细胞进入死亡途径。一些热带病具有可应用光敏剂和局部光照的生理病理方面。此外，疾病可能通过受感染的献血传播，并且与热带病相关的许多病因已被证明易受光动力方法的影响。然而，尚未系统研究光抗菌剂在各种情况下的应用，无论是针对人类疾病还是血液制品的消毒，甚至作为光杀虫剂。我们旨在本综述中报告对寄生虫治疗领域有益的光抗菌方法的进展，并且还有可能为服务不足的人群开发低成本/高效率的方案提供便利。
