Laboratory of Neurogenetics and Development, Weill Medical College of Cornell University, New York 1065, New York, USA.
Dev Neurobiol. 2011 Jan 1;71(1):2-9. doi: 10.1002/dneu.20823.
The regulation of progenitor proliferation in developing brain in has been extensively studied in the cerebral cortex, but relatively little is known about progenitor divisions in ventral germinal zones. Recent observations pertinent to interneuron genesis in the ventral forebrain, especially in the medial ganglionic eminence, indicate similarities to cerebral cortical neurogenesis and hint at some interesting differences between ventral and dorsal telencephalon progenitors. Proliferation within the ganglionic eminences is discussed from the vantage point of neural precursor cell cycles, especially G1-phase, and current models of neurogenic divisions in cortex that may apply to ventral forebrain as well.
发育中大脑的祖细胞增殖调控在大脑皮层中得到了广泛研究，但对于腹侧神经生发区中的祖细胞分裂知之甚少。最近关于腹侧前脑（尤其是内侧神经节隆起）中中间神经元发生的观察结果表明，其与大脑皮层神经发生具有相似性，并暗示了腹侧和背侧端脑祖细胞之间的一些有趣差异。本文从神经前体细胞周期，特别是 G1 期的角度讨论了神经节隆起内的增殖，并讨论了可能适用于腹侧前脑的皮质神经发生分裂的当前模型。
