Ge Jianye, Budowle Bruce, Chakraborty Ranajit
Institute of Investigative Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
J Forensic Sci. 2011 Jan;56 Suppl 1:S23-8. doi: 10.1111/j.1556-4029.2010.01631.x. Epub 2010 Dec 13.
DNA-based analysis is integral to missing person identification cases. When direct references are not available, indirect relative references can be used to identify missing persons by kinship analysis. Generally, more reference relatives render greater accuracy of identification. However, it is costly to type multiple references. Thus, at times, decisions may need to be made on which relatives to type. In this study, pedigrees for 37 common reference scenarios with 13 CODIS STRs were simulated to rank the information content of different combinations of relatives. The results confirm that first-order relatives (parents and fullsibs) are the most preferred relatives to identify missing persons; fullsibs are also informative. Less genetic dependence between references provides a higher on average likelihood ratio. Distant relatives may not be helpful solely by autosomal markers. But lineage-based Y chromosome and mitochondrial DNA markers can increase the likelihood ratio or serve as filters to exclude putative relationships.
基于DNA的分析对于失踪人员身份鉴定案件至关重要。当无法获得直接参考样本时，可以通过亲缘关系分析使用间接的亲属参考样本以识别失踪人员。一般来说，更多的参考亲属会使鉴定准确性更高。然而，对多个参考样本进行分型成本很高。因此，有时可能需要决定对哪些亲属进行分型。在本研究中，模拟了37种常见参考情况的家系，使用13个CODIS STR进行分析，以对不同亲属组合的信息含量进行排序。结果证实，一级亲属（父母和同胞）是识别失踪人员的首选亲属；同胞也具有参考价值。参考样本之间较低的遗传相关性平均提供了更高的似然比。仅依靠常染色体标记，远亲可能没有帮助。但基于谱系的Y染色体和线粒体DNA标记可以增加似然比或作为排除假定关系的筛选工具。
