聚焦生物关节置换。
Homing in on a biological joint replacement.
机构信息
Departments of Orthopaedic Surgery and Biomedical Engineering, Duke, University Medical Center, Durham, NC 27710, USA.
出版信息
Stem Cell Res Ther. 2010 Dec 14;1(5):40. doi: 10.1186/scrt40.
Abstract
The use of tissue engineering therapies for treating damaged articular cartilage has traditionally focused on cell-based therapies for the repair of focal chondral or osteochondral defects. A recent study by Lee and colleagues in the Lancet shows exciting proof-of-concept that an acellular scaffold containing transforming growth factor beta 3 can induce homing of cells that regenerate a hyaline-like cartilage surface. These findings provide a glimpse into the possibility that tissue engineering may in fact provide the means for regeneration of an entire joint surface, beyond a simple focal defect in the articular cartilage.
摘要
传统上，使用组织工程疗法治疗受损的关节软骨一直集中在基于细胞的疗法上，用于修复局灶性软骨或骨软骨缺损。最近，李博士及其同事在《柳叶刀》上的一项研究提供了令人兴奋的概念验证，表明含有转化生长因子 β3 的细胞外基质支架可以诱导细胞归巢，从而再生类似透明软骨的软骨表面。这些发现让人们看到了组织工程技术的可能性，它实际上可能为整个关节表面的再生提供了一种手段，而不仅仅是关节软骨的简单局灶性缺损。
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