聚焦生物关节置换。
Homing in on a biological joint replacement.
机构信息
Departments of Orthopaedic Surgery and Biomedical Engineering, Duke, University Medical Center, Durham, NC 27710, USA.
出版信息
Stem Cell Res Ther. 2010 Dec 14;1(5):40. doi: 10.1186/scrt40.
Abstract
The use of tissue engineering therapies for treating damaged articular cartilage has traditionally focused on cell-based therapies for the repair of focal chondral or osteochondral defects. A recent study by Lee and colleagues in the Lancet shows exciting proof-of-concept that an acellular scaffold containing transforming growth factor beta 3 can induce homing of cells that regenerate a hyaline-like cartilage surface. These findings provide a glimpse into the possibility that tissue engineering may in fact provide the means for regeneration of an entire joint surface, beyond a simple focal defect in the articular cartilage.
摘要
传统上，使用组织工程疗法治疗受损的关节软骨一直集中在基于细胞的疗法上，用于修复局灶性软骨或骨软骨缺损。最近，李博士及其同事在《柳叶刀》上的一项研究提供了令人兴奋的概念验证，表明含有转化生长因子 β3 的细胞外基质支架可以诱导细胞归巢，从而再生类似透明软骨的软骨表面。这些发现让人们看到了组织工程技术的可能性，它实际上可能为整个关节表面的再生提供了一种手段，而不仅仅是关节软骨的简单局灶性缺损。
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2
Failed metal-on-metal hip arthroplasties: a spectrum of clinical presentations and operative findings.金属对金属髋关节置换失败：一系列临床表现和手术发现。
Clin Orthop Relat Res. 2010 Sep;468(9):2313-20. doi: 10.1007/s11999-010-1419-0.
3
Considerations for tissue-engineered and regenerative medicine product development prior to clinical trials in the United States.考虑在美国临床试验之前进行组织工程和再生医学产品的开发。
Tissue Eng Part B Rev. 2010 Feb;16(1):41-54. doi: 10.1089/ten.TEB.2009.0449.
4
Rapid prototyping of anatomically shaped, tissue-engineered implants for restoring congruent articulating surfaces in small joints.用于修复小关节中协调关节面的解剖形状组织工程植入物的快速成型。
Cell Prolif. 2009 Aug;42(4):485-97. doi: 10.1111/j.1365-2184.2009.00608.x. Epub 2009 May 22.
5
Clinical transplantation of a tissue-engineered airway.组织工程气道的临床移植
Lancet. 2008 Dec 13;372(9655):2023-30. doi: 10.1016/S0140-6736(08)61598-6. Epub 2008 Nov 18.
6
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Tissue Eng Part A. 2008 Jul;14(7):1195-202. doi: 10.1089/ten.tea.2007.0186.
7
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